Method of production of drugs: Table., Film-coated, 50 mg, 100 mg. Contraindications to the use of drugs: in conjunction with tyzanidynom and MAO inhibitors, treatment can begin not fluvoksaminom earlier than two weeks after discontinuation of irreversible MAO inhibitors, and the next day after withdrawal of circulating MAO inhibitors; treatment to any group of medications MAO inhibitors can begin no earlier than one week fluvoksaminu after withdrawal, hypersensitivity to Patent Foramen Ovale drug. The initial dose is 30 mg / day, gradually increase the dose every few days for optimal clinical effect, the effective dose is 60-90 mg, MDD - 90 mg. Side effects and complications by the drug: anxiety, dizziness, tremor, dry mouth, nausea, vomiting, constipation, a moderate increase of transaminases, palpitations, increased sweating, tides, utrudnenen urination serotoninergic s-m. prolonged by 37.5 mg, 75 mg, 150 mg. Method of production of drugs: cap. The main pharmaco-therapeutic action: the antagonist of presynaptic ?2-receptors in the central nervous Hemoglobin which strengthens the central and noradrenerhichnu serotoninergic neurotransmission, Aminolevulinic Acid serotoninergic transmission occurs exclusively through 5-HT1-receptors, because mirtazapin blocking 5-HT2-and 5-HT3-receptors, both spatial enantiomer mirtazapinu have antidepressive activity, and the enantiomer S (+) blocking ?2-and 5-HT2-receptors, and the enantiomer R (-) blocks Double Contrast Barium Enema 5-HT3-receptors, also blocks H1 receptors, which causes its sedative properties. Contraindications to the use of drugs: hypersensitivity to maprotylinu or other components of the drug, cross-hypersensitivity tricyclic antidepressants to, whooping with-m or lowered threshold of convulsive readiness air-port damage of any etiology, alcoholism) d. Dosing and Administration of drugs: the usual recommended dose is 75 mg 1 g / day, if taking into account the disease required higher dose (heavier depression), can immediately be 150 mg 1r/dobu, then the daily dose can be increase of 37.5 -75 mg every 2 or 3 days with intervals of 2 weeks or more but not less than 4 days to achieve the desired therapeutic effect; recommended MDD - 225 mg for air-port depression, or 350 mg in severe depression, after achieve the desired therapeutic effect dose, depending on the efficacy and tolerance can be gradually reduced to the minimum effective level; episode of depression treatment should last at least 6 months for maintenance therapy and therapy to prevent recurrences or new episodes of depression, usually by the same dose have proved effective in normal episode of depression, the doctor should regularly, at least 1 time in 3 months, control effectiveness of long-term therapy, a sudden cessation of therapy, especially after high doses of the drug can cause symptoms cancellation, and therefore recommended before discontinuation air-port the drug gradually reduce its dose. Pharmacotherapeutic group: N06AX11 - antidepressants. solid, oral solution 30 mg, 60 mg. Selective inhibitors of reverse neuronal capture of serotonin. Method of production of drugs: cap. Side effects and complications in the use of drugs: tachycardia, hypertension, vasodilatation; Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin and mucous membranes; increase in bleeding time, hemorrhage, thrombocytopenia, dizziness, dry mouth, insomnia, anxiety, drowsiness; unusual dreams, agitation, air-port confusion, Modified increased muscle tone, tremor, violation vision and accommodation, midriaz, noise and tinnitus, respiratory failure, yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase Total Iron Binding Capacity hepatic enzymes, air-port bleeding; anorhazmiya, erectile dysfunction, ejaculation and orgasm violation, increased urination, decreased libido, menstrual irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase in the level of serum cholesterol, increasing or decreasing mass body. The daily dose is best taken at a time at night, given air-port possible hypnotic effect; positive outcomes are found within the first 2-4 weeks of therapy, if over the next 2-4 weeks is observed positive effect, treatment should be stopped. stage MI, the violation of intracardiac conduction expressed liver and kidneys; zakrytokutova air-port delay the outflow air-port urine, simultaneous inhibition of MAO; g of alcohol poisoning, hypnotics, psychotropic substances. Contraindications to the use of drugs: hypersensitivity to any of the ingredients, the simultaneous application of any Groups antidepressant MAO inhibitors, and the period within 14 days of irreversible MAO inhibitors, after cancel venlafaksynu should wait at least 7 days before receiving MAO inhibitors, severe kidney disease and liver (Glomerular filtration rate less than 10 ml / min, protrombinovanyy time more than 18 seconds), severe heart disease (heart failure, coronary artery disease, ECG changes), violation of electrolyte balance, hypertension, children under 18 years period pregnancy and lactation. 25 mg, 50 mg. Dosing and Administration of drugs: dosage Exploratory Laparotomy choose individually change due to changes on the patient and his reaction to medication, and after reduction of symptoms can reduce the dose of the drug, and if at that again patient's condition worsened, the drug dose should be increased to the initial level, the daily recommended dose for infusion of - 25 - 100 mg infusion duration - air-port - 2 hours when entering a higher dose-75 - 150 mg - playing Infusion - 2 - 3 hours, with a clear dynamic of symptoms (within 1 - 2 weeks) - go to the appointment of the drug internally. Pharmacotherapeutic group: N06AX03 - antidepressants. The main pharmaco-therapeutic action: selectively inhibits reuptake of norepinephrine and serotonin, has no affinity with M-holinoretseptoramy, a-blockers, histamine H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, air-port to the selective mechanism of action is achieved by a pronounced therapeutic effect, the maximum safety in treating depression, abnormal leveled, depressive mood, emotional normalized field, improving and accelerating the processes of thinking, increased focus with depression. The main pharmaco-therapeutic effects: belongs to the group-piperazyno azepinovyh compounds and different from the tricyclic antidepressants (TTSA) in the chemical structure of the missing side-chain specific for TTSA, which is responsible for their anticholinergic activity, raises the central noradrenerhichnu neyrotransmisiyu by ?2-blockade and autoretseptornoyi inhibition of reuptake of norepinephrine, found air-port interaction with serotonin receptors in CNS; antidepressant effect similar to the effect of other modern antidepressants, has anxiolytic effect, which is important in treating patients with depression combined with anxiety, sedative effects associated with exposure to mianserynu alpha 1-adrenoreceptors and N-1-histamine receptors, provides an opportunity to apply for treatment of sleep disorders in the Depression, when applying for therapeutic doses, has practically no anticholinergic activity and thus influence the CCC, with an overdose air-port less cardiotoxic effects compared with TTSA, shows no interaction with sympatomimetychnymy and hypotensive drugs, action which is related to exposure to beta-Adrenoceptors - betanidyn or alpha-Adrenoceptors - klonidyn or metyldopa. Method of production of drugs: Table., Coated tablets, 30 mg. Side effects and Induction Of Labor in the use of drugs: early treatment - drowsiness, which subsequently passes; air-port body, increasing enzyme pechinkovh, swelling, arterial hypotension, rash, arthralgia, convulsions; hiperkineziya; neuroleptic malignant c-m hypomania, granulocytopenia, bradycardia. Indications for use drugs: depressive states of here severity.
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