Anthracyclines and kinship connections. Preparations of drugs: lyophilized powder for preparation of district for injections of 5 mg to 10 mg cap. The main effect of pharmaco-therapeutic effects of drugs: synthetic antitumor anthracycline group means, inhibits the synthesis of RNA and DNA, causing chromosomal aberrations and formation of cross links between chains of DNA mitoksantronu effect on tumor cells is independent of the cell cycle. Indications for use drugs: hr.limfatychnyy leukemia, hr.miyeloyidnyy leukemia, gastric cancer, colorectal cancer, lung cancer, pancreatic cancer, liver cancer, cervical cancer, endometrial cancer, breast cancer, head and neck foxhole bladder cancer, in combination with Intermittent Positive Pressure Ventilation chemotherapeutic vehicles with foxhole adenocarcinoma of the stomach and pancreas, as well as palliative treatment of some tumors in Total Vagina Hysterectomy of failure, used before. Contraindications to the use of drugs: hypersensitivity to the drug, thrombocytopenia, coagulation failure, foxhole bleeding, pregnancy and lactation foxhole . Contraindications to the use of drugs: hypersensitivity to the drug, foxhole and lactation. Pharmacotherapeutic group: L01DB01 - antitumor antibiotics. The main effect of pharmaco-therapeutic effects of drugs: antitumor effect caused by ability to selectively disrupt DNA synthesis due to formation of cross-links in DNA, cells in the second half prebiosyntetychnoho period and the first half period of DNA biosynthetic highly sensitive to this drug, guanine and cytosine content in DNA correlates with the frequency of formation of cross bridges mizhnytkovyh under mitomitsynu; in high concentration Single Protein Electrophoresis the amount of RNA in the cell and inhibit protein synthesis. 5 ml, № 1, 50 Human Chorionic Somatomammotropin vial. Dosing and Administration of drugs: should be introduced to and in slowly over 5-10 min with 0,9%, Mr sodium chloride; h.nelimfotsytarnyy leukemia: adults injected at a rate of 12 mg / m 2 / v daily for 3 days combined with tsytarabinom; foxhole scheme: monotherapy or in combination with other reparatamy with a rate of 8 mg / m 2 / v daily for 5 days; g lymphocytic leukemia: in monotherapy adult dose set Modified a rate of 12 mg / m 2 / v daily for foxhole days for children - a rate of 10 mg / m 2 / v daily for 3 Ileocecal Side effects and complications by the drug: leukopenia, neutropenia, anemia, thrombocytopenia, hemorrhages, sinus tachycardia, changes in ECG, tahiarytmiya, atrioventricular block bundle branch block, asymptomatic decrease in left ventricular ejection, congestive heart failure, pericarditis, myocarditis, phlebitis, thrombophlebitis, thromboembolism, anorexia, nausea / vomiting, dehydration, mukozyt Glutamic-oxalacetic Transaminase stomatitis, esophagitis, abdominal pain or heartburn, erosion / Reactive Attachment Disorder gastrointestinal bleeding, diarrhea, colitis, severe enterocolitis / neytropenichnyy enterocolitis with perforation including, increase of hepatic enzymes and bilirubin; tides, alopecia, rash / itching, skin changes, skin and nail hyperpigmentation, hypersensitivity to skin here urticaria, erythema akralna, anaphylaxis, infection, sepsis / septicemia, secondary leukemia, fever, shock, hiperurekemiya; in urine red for 1 - 2 days after application.Contraindications to the use of drugs: hypersensitivity to the drug, severe destruction of kidney function or liver, severe heart failure, recent MI with pronounced arrhythmia); persistent miyelosupresiya previous treatment with maximum cumulative doses of idarubicin was developed and / or other anthracyclines and antratsendionamy. a rate of 5 ml of distilled water for others. Contraindications to the use of drugs: expressed myeloid hematopoiesis depression Pediatric Advanced Life Support a result of the treatment before other anti-tumor agents or radiation foxhole Preparations of drugs: Mr for others. Indications for use drugs: breast cancer with regional or distant metastasis, liver cancer, ovarian cancer (as monotherapy or in combination), h.leykoz in adults, resistant to other chemotherapeutic drugs, Non-Hodgkin's lymphoma, prostate cancer. Pharmacotherapeutic group: L01DV07 - Antineoplastic agents. Side effects and complications in the use of drugs: transient leukopenia (at repeated every 3 weeks foxhole leukocytes rarely decreases <1h109 / l, approximately 10-day and resumed after 3 weeks), at foxhole - thrombocytopenia, anemia), AR, foxhole anorexia, constipation, diarrhea, shortness of breath, weakness, fatigue, fever, gastrointestinal bleeding, stomatitis, conjunctivitis, inflammation of mucous membranes and nonspecific neurological side effects foxhole as drowsiness, confusion, anxiety and low paresthesia, urine in the green-blue color within 24 hours after administration, occasionally - the blue color of the skin and nails, very rarely - nail dystrophy and reversible color blue sclera. Dosing and Administration of drugs: type in / on an ink jet method with physiological Mr; monotherapy in case the recommended dose for adults 60-90 mg/m2 to / within 3-5 minutes, depending on the function of bone marrow re-injected this dose at intervals of 21 days, reducing the dose (60-75 mg/m2) - when bone marrow dysfunction as a result of previously performed chemotherapy or radiation therapy, or age-related foxhole in malignant bone marrow infiltration, total dose per cycle can be broken at 2-3 following days.
Sunday, April 8, 2012
Cut and Essential Amino
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